PEPTIQORE IMPURITY INTELLIGENCE
Peptide Impurity Database
Evidence-classified impurity records for priority GLP-1 class peptides. Filter by parent peptide, impurity category, evidence status and reference material availability.
10 records found
All records are classified by evidence source. Evidence status reflects the quality of available scientific support, not commercial availability. Records without sufficient evidence are not published.
Semaglutide Met Oxidation Impurity
Parent: Semaglutide
Oxidation product at methionine residue(s) in the semaglutide sequence. Met oxidation is a well-characterized degradation pathway for GLP-1 analogues.
Semaglutide Deamidation Impurity
Parent: Semaglutide
Deamidation product at asparagine residue(s) in the semaglutide sequence. Deamidation is a relevant degradation pathway under stressed conditions.
Semaglutide Des-Fatty Acid Impurity
Parent: Semaglutide
Semaglutide peptide backbone without the C18 fatty diacid side chain. Loss of the fatty acid modification is a relevant process and degradation impurity.
Semaglutide [D-His¹] Epimer
Parent: Semaglutide
Epimeric impurity at the N-terminal histidine residue. D-amino acid incorporation at position 1 is a known sequence-related impurity in GLP-1 analogues.
Tirzepatide Met Oxidation Impurity
Parent: Tirzepatide
Oxidation product at methionine residue(s) in the tirzepatide sequence.
Tirzepatide Des-Fatty Acid Impurity
Parent: Tirzepatide
Tirzepatide peptide backbone without the C20 fatty diacid side chain.
Liraglutide Des-Fatty Acid Impurity
Liraglutide Backbone Peptide
Parent: Liraglutide
Liraglutide peptide backbone without the C16 fatty acid side chain. Loss of the palmitic acid modification via hydrolysis of the glutamic acid spacer linkage is a primary degradation and process-related impurity. This impurity has reduced albumin-binding affinity and altered pharmacokinetic profile.
Liraglutide Met Oxidation Impurity
Parent: Liraglutide
Oxidation product at methionine residue(s) in the liraglutide sequence. Met oxidation is a well-characterised degradation pathway for GLP-1 analogues under oxidative stress conditions. The oxidised form may be detected by LC-MS as a +16 Da mass shift.
Liraglutide Deamidation Impurity
Parent: Liraglutide
Deamidation product at asparagine or glutamine residue(s) in the liraglutide sequence. Deamidation introduces a +1 Da mass shift and may affect chromatographic retention. Relevant under acidic or elevated temperature stress conditions.
Liraglutide [Arg³⁴] Sequence Variant
Liraglutide Arg34 Impurity
Parent: Liraglutide
Sequence variant with arginine at position 34. Liraglutide contains a Lys³⁴→Arg³⁴ substitution relative to native GLP-1(7-37); this impurity arises from incomplete or incorrect amino acid incorporation during synthesis. Reported in the scientific literature as a relevant process-related impurity.