PEPTIQORE QUALITY RECORD
Semaglutide Quality Intelligence
Semaglutide is a GLP-1 receptor agonist peptide with a C18 fatty diacid side chain attached via a mini-PEG linker and a gamma-glutamic acid spacer to lysine at position 26. The fatty acid modification enables albumin binding and extends the plasma half-life to approximately one week, enabling once-weekly dosing.
QUALITY RECORD
PQ-PEP-000001RECORD TYPE
Therapeutic Peptide
PEPTIQORE ID
PQ-PEP-000001
CAS NUMBER
910463-68-2
MOLECULAR WEIGHT
4113.6 Da
AMINO ACIDS
31
RECORD VERSION
1.0
RECORD COMPLETENESS
IDENTITY
Semaglutide Identity
Semaglutide is a GLP-1 receptor agonist peptide with a C18 fatty diacid side chain attached via a mini-PEG linker and a gamma-glutamic acid spacer to lysine at position 26. The fatty acid modification enables albumin binding and extends the plasma half-life to approximately one week, enabling once-weekly dosing.
MOLECULAR FORMULA
C₁₈₇H₂₉₁N₄₅O₅₉
CALCULATED MW
4113.6 Da
CAS NUMBER
910463-68-2
AMINO ACID COUNT
31
QUALITY RISKS
Relevant Quality Pathways
Based on published literature and regulatory data. Not all pathways necessarily occur in every batch.
Oxidation
Met oxidation is a relevant degradation pathway
Deamidation
Asn deamidation under stressed conditions
Hydrolysis
Fatty acid side chain hydrolysis
Isomerization
Asp isomerization
Aggregation
Aggregation-related species
QUALITY MAP
Semaglutide Quality Map
Relevant quality pathways and impurity categories. Data completeness varies by category.
Process-Related Impurities
Synthesis, modification, coupling, cleavage or purification
- Des-fatty acid impurity (loss of C18 side chain)
- Incompletely modified lysine variants
- Linker-related impurities
- Regioisomeric acylation variants
Relevant quality pathways — not all necessarily present in every batch.
Sequence-Related Impurities
Deletion, insertion, truncation and epimeric variants
- Deletion variants (single amino acid deletions)
- Truncated sequences (N- or C-terminal truncations)
- Epimeric variants (D-amino acid incorporation)
- Incorrect sequence variants
Only list specific impurities when supported by credible source or PeptiQore experimental record.
Degradation-Related Impurities
Oxidation, deamidation, hydrolysis and other degradation pathways
- Met oxidation products
- Asn deamidation products
- Fatty acid side chain hydrolysis products
- Asp isomerization products
Relevant quality pathways based on published literature and regulatory data.
IMPURITY LIBRARY
Semaglutide Impurity Records
Semaglutide Met Oxidation Impurity
Degradation-related · Oxidation-related
Semaglutide Deamidation Impurity
Degradation-related · Deamidation-related
Semaglutide Des-Fatty Acid Impurity
Degradation-related · Process-related
Semaglutide [D-His¹] Epimer
Sequence-related · Epimeric
QUALITY GRAPH
Semaglutide Knowledge Graph
Connected quality knowledge — not a product catalog.
QUALITY INTELLIGENCE
Analyze Semaglutide Quality Risk
Use PeptiQore Intelligence to explore degradation pathways, interpret mass shifts, investigate unknown peaks and review impurity strategy for semaglutide.
COMMERCIAL SUPPORT
Semaglutide Quality Support
Request Reference Material
Semaglutide parent or impurity reference material for analytical use.
Request Reference MaterialRequest Custom Synthesis
Custom synthesis of semaglutide-related impurities not in the standard catalog.
Request Custom SynthesisInvestigate Unknown Peak
Unexpected chromatographic peak in your semaglutide sample requiring investigation.
Investigate Unknown PeakSOURCES & EVIDENCE
PeptiQore provides scientific information for professional laboratory, development and quality-control use. Public database content may include literature-derived, regulatory, experimental and computational information. Users should evaluate source and evidence status before applying information to regulated decisions.