SEMAGLUTIDE · IMPURITY LIBRARY
Semaglutide Impurities
Explore reported, characterized and custom-developed semaglutide-related impurities, analytical reference materials and quality-support options.
IMPURITY RECORDS
Characterized Impurities
Semaglutide Met Oxidation Impurity
Degradation-related · Oxidation-related
Oxidation product at methionine residue(s) in the semaglutide sequence. Met oxidation is a well-characterized degradation pathway for GLP-1 analogues.
Semaglutide Deamidation Impurity
Degradation-related · Deamidation-related
Deamidation product at asparagine residue(s) in the semaglutide sequence. Deamidation is a relevant degradation pathway under stressed conditions.
Semaglutide Des-Fatty Acid Impurity
Degradation-related · Process-related
Semaglutide peptide backbone without the C18 fatty diacid side chain. Loss of the fatty acid modification is a relevant process and degradation impurity.
Semaglutide [D-His¹] Epimer
Sequence-related · Epimeric
Epimeric impurity at the N-terminal histidine residue. D-amino acid incorporation at position 1 is a known sequence-related impurity in GLP-1 analogues.
IMPURITY CATEGORIES
Semaglutide Impurity Landscape
Relevant quality pathways based on published literature and regulatory data. Not all categories necessarily apply to every batch.
Process-Related Impurities
- Des-fatty acid impurity
- Incompletely modified lysine variants
- Linker-related impurities
- Regioisomeric acylation variants
Sequence-Related Impurities
- Deletion variants
- Truncated sequences
- Epimeric variants (D-amino acid)
- Incorrect sequence variants
Degradation-Related Impurities
- Met oxidation products
- Asn deamidation products
- Fatty acid hydrolysis products
- Asp isomerization products
CUSTOM SYNTHESIS
Impurity Not Listed?
PeptiQore can assess custom synthesis and analytical characterization of semaglutide-related impurities not available in the standard catalog.
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Have an Unknown Peak?
Unexpected chromatographic peak in your semaglutide sample? PeptiQore can support analytical investigation and candidate identification.
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