Liraglutide Degradation Pathways

Evidence-based degradation pathway intelligence for liraglutide. Covers fatty acid side chain hydrolysis, oxidative degradation, deamidation and sequence-related impurities.

Degradation pathway information is based on published literature and regulatory data. Actual degradation profiles depend on formulation, storage conditions and manufacturing process.

Fatty Acid Side Chain Hydrolysis

Hydrolysis

Regulatory/Public

DEGRADATION PRODUCT

Des-fatty acid impurity

CONDITIONS

Aqueous conditions, elevated temperature, acidic or basic pH

SIGNIFICANCE

Primary degradation pathway; des-fatty acid impurity is a key quality attribute

Methionine Oxidation

Oxidation

Peer-reviewed Literature

DEGRADATION PRODUCT

Met oxidation impurity (+16 Da)

CONDITIONS

Oxidative stress, peroxide exposure, light

SIGNIFICANCE

Relevant degradation pathway under stressed conditions

Asparagine/Glutamine Deamidation

Deamidation

Peer-reviewed Literature

DEGRADATION PRODUCT

Deamidation impurity (+1 Da)

CONDITIONS

Acidic or basic pH, elevated temperature

SIGNIFICANCE

Relevant under stressed conditions; detectable by LC-MS

STABILITY STUDY SUPPORT

PeptiQore supports forced degradation study design, stability-indicating method development and stability testing for liraglutide programs.

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