PEPTIQORE QUALITY RECORD
Tirzepatide Quality Intelligence
Tirzepatide is a dual GIP and GLP-1 receptor agonist peptide with a C20 fatty diacid side chain. The dual agonism mechanism distinguishes it from selective GLP-1 agonists and introduces additional complexity in impurity profiling and analytical characterization.
QUALITY RECORD
PQ-PEP-000002RECORD TYPE
Therapeutic Peptide
PEPTIQORE ID
PQ-PEP-000002
CAS NUMBER
2023788-19-2
MOLECULAR WEIGHT
4813.5 Da
AMINO ACIDS
39
RECORD VERSION
1.0
RECORD COMPLETENESS
IDENTITY
Tirzepatide Identity
Tirzepatide is a 39-amino acid dual GIP and GLP-1 receptor agonist with a C20 fatty diacid side chain attached via a linker to lysine at position 20. The dual receptor agonism mechanism and longer peptide chain introduce additional complexity in synthesis, impurity profiling and analytical characterization relative to selective GLP-1 analogues.
MOLECULAR FORMULA
C₂₂₅H₃₄₈N₄₈O₆₈
CALCULATED MW
4813.5 Da
CAS NUMBER
2023788-19-2
AMINO ACID COUNT
39
QUALITY RISKS
Relevant Quality Pathways
Based on published literature and regulatory data. Not all pathways necessarily occur in every batch. Dual agonist structure introduces additional analytical complexity.
Oxidation
Met oxidation is a relevant degradation pathway
Deamidation
Asn/Gln deamidation under stressed conditions
Hydrolysis
Fatty acid side chain hydrolysis
Isomerization
Asp isomerization
Aggregation
Aggregation-related species
QUALITY MAP
Tirzepatide Quality Map
Relevant quality pathways and impurity categories. Data completeness varies by category.
Process-Related Impurities
Synthesis, modification, coupling, cleavage or purification
- Des-fatty acid impurity (loss of C20 side chain)
- Incompletely modified lysine variants
- Linker-related impurities
Relevant quality pathways — not all necessarily present in every batch.
Sequence-Related Impurities
Deletion, insertion, truncation and epimeric variants
- Deletion variants
- Truncated sequences
- Epimeric variants
Dual agonist structure introduces additional complexity relative to selective GLP-1 analogues.
Degradation-Related Impurities
Oxidation, deamidation, hydrolysis and other degradation pathways
- Met oxidation products
- Asn/Gln deamidation products
- Fatty acid side chain hydrolysis products
Relevant quality pathways based on published literature.
IMPURITY LIBRARY
Tirzepatide Impurity Records
QUALITY GRAPH
Tirzepatide Knowledge Graph
Connected quality knowledge — not a product catalog.
QUALITY INTELLIGENCE
Analyze Tirzepatide Quality Risk
Use PeptiQore Intelligence to explore degradation pathways, interpret mass shifts, investigate unknown peaks and review impurity strategy for tirzepatide.
COMMERCIAL SUPPORT
Tirzepatide Quality Support
Request Reference Material
Tirzepatide parent or impurity reference material for analytical use.
Request Reference MaterialRequest Custom Synthesis
Custom synthesis of tirzepatide-related impurities not in the standard catalog.
Request Custom SynthesisInvestigate Unknown Peak
Unexpected chromatographic peak in your tirzepatide sample requiring investigation.
Investigate Unknown PeakSOURCES & EVIDENCE
PeptiQore provides scientific information for professional laboratory, development and quality-control use. Public database content may include literature-derived, regulatory, experimental and computational information. Users should evaluate source and evidence status before applying information to regulated decisions.