Des-His¹ Semaglutide Deletion Impurity Reference Material
Used as a reference standard for identification and quantification of N-terminal deletion impurities in Semaglutide drug substance and drug product.
PARENT PEPTIDE
Semaglutide
MATERIAL TYPE
Sequence-Related Impurity
TARGET PURITY
≥90% (HPLC)
EVIDENCE STATUS
Peer-Reviewed
QUANTITY
DOCUMENTATION
QUALITY CONTEXT
Why This Record Matters
N-terminal deletion impurities are among the most analytically relevant sequence-related impurities for GLP-1 receptor agonist peptides. Des-His¹ represents loss of the first residue during synthesis.
POTENTIAL ORIGIN
Incomplete coupling or premature termination during solid-phase peptide synthesis at position 1.
Analytical Data Package
PEPTIQORE APPROACH
TRADITIONAL SUPPLIER
Product → CoA
IMPURITY CLASSIFICATION
Sequence-Related ImpurityEVIDENCE STATUS
Peer-ReviewedPARENT PEPTIDE
Semaglutide Quality Hub →RELATED ANALYTICAL MATERIALS
CUSTOM DEVELOPMENT
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